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Polyphenols have been extensively studied for their ability to regulate inflammatory responses by modulating the activity of pro-inflammatory genes and influencing signal transduction pathways, thereby reducing neuroinflammation and neuronal death

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Secondary enzymes such as thioredoxins (TRXs), thioredoxin reductases (TRRs), peroxidases (PRXs), and glutaredoxins (GRXs) further bolster antioxidant defenses