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During activation, the agonist GABA exclusively binds to the VFTD cleft of GB1, triggering the closure of the GB1-VFTD, whereas the GB2-VFTD remains in an open conformation (Fig

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Yu S., Tang Q., Chen G., et al., “Circadian Rhythm Modulates Endochondral Bone Formation via MTR1/AMPKbeta1/BMAL1 Signaling Axis,” Cell Death and Differentiation 29, no