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The metabolic and liver histological benefits of chow-reversal were accompanied by restored intestinal barrier, reversal of loss in colon weight and length and reduced markers of colon fibrosis (PSR, Col1a1) and inflammation (CD45, CD3)

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Because DSIP is studied in the context of sleep architecture normalization, stress response modulation, and HPA axis regulation, it is a subject in experiments related to sleep-stress interactions and emotional well-being—without implying outcomes outside of a research setting.