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TNF-α is a powerful systemic proinflammatory cytokine, generated primarily by stimulatory macrophages that are believed to play a decisive part in COPD pathogenesis by promoting and maintaining expression and releasing of many proinflammatory mediators that lead to tissue damage and remodeling

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Vitamin B12 injection is currently licensed for use in maintenance therapy for pernicious anaemia every 2 – 3 months depending on the type of pernicious anaemia