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It has been suggested that death signals flows from RIP1 to RIP3 through their RHIM domains, resulting in recruitment of additional RIP3 molecules for signal propagation, implying that RIP3 oligomerization is the minimal functional unit that is required to drive necrosome assembly [121]

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Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation

It also plays a key role in the immune system