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First Trimester During the first 6–8 weeks of pregnancy, with the placenta not yet completely attached to maternal circulation, the uterine spiral arteries are blocked by intraluminal cytotrophoblast and a physiological and local hypoxia is generated

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Phytochemicals (polyphenols, flavonoids, terpenoids) reduce selenium ions and also get adsorbed to the nascent nanoparticle surfaces as a capping agent, resulting in steric stabilisation and imparting biological functionality (antioxidant motifs, targeting ligands) (Singaravelu et al., 2025)