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The authors also highlight some of the issues in clinical trials of herbal medicines given that currently available evidence on herbal medicines for tinnitus is overall of insufficient quality and the conclusions from existing trials are conflicting

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GHK-Cu’s documented NGF stimulation appears to sit within its broader gene expression modulation signature rather than representing a direct receptor interaction, which is mechanistically coherent with the transcriptomic reactivation data showing GHK-Cu shifting aging gene expression profiles toward younger patterns (PMID: 25904764)