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Thus, we combined the pan-neuronal expression of G4C2x36 or GR36 with genetic manipulations to promote fission (overexpression of pro-fission factors Drp1 or Mff [ Tango11 in Drosophila ]) or reduce fusion (loss of pro-fusion factors Opa1 and Mitofusin [ Marf in Drosophila ])

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