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A direct comparative assessment of the aqueous solubility and reconstitution behavior of AOD-9604 versus older legacy formulations indicates that optimized excipient ratios and tailored polar-nonpolar residue distributions prevent unwanted molecular aggregation, allowing for rapid, crystal-clear stock solution preparation without requiring harsh co-solvents or extreme physical agitation

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10.1016/j.bbrc.2016.09.046 321 SongZ.MaoJ.BarreroR