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Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin

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36 Although the mechanism of bilirubin-induced neurotoxicity is not completely understood, it is clear that G6PD deficiency contributes to kernicterus via at least two mechanisms: initially, through increased hemolysis-induced spike in serum bilirubin levels and subsequent accumulation of bilirubin in the brain, and secondly, by reduced buffering capacity against bilirubin-induced ROS (Fig