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The Compound Classes Most Studied in Tendon Research Tendon healing is limited by three biological constraints: low resident cell density (tenocytes proliferate slowly), poor vascularization (tendons have limited baseline blood supply), and structured extracellular matrix requirements (collagen must reorganize into the correct fibril architecture for functional recovery)

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However, for severe malabsorption or rapid repletion, direct routes like injections or high-dose sublingual are often superior