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In the head-to-head SURMOUNT-5 trial (NEJM 2025), tirzepatide produced −20.2% weight loss vs −13.7% for semaglutide

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The absence of a determined lethal dose in rodent studies reflects that acute toxicity testing did not reach a fatal threshold at doses tested, not that the compound has been proven safe at all doses or via all routes over extended periods in any species