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And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat

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Therefore, researchers studying lipolysis in pituitary-suppressed models, GH-receptor knockout animals, or in vitro adipocyte cultures use AOD 9604, while researchers requiring intact GH axis function use Tesamorelin