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Large numbers of phagocytic macrophages persist in the COI for over 4 weeks apparently sustained by a mechanism of a vicious cycle where damaged myelin is potently chemotactic and chemokines elevated, resulting in activation of infiltrating macrophages that coincides with additional damage to the surrounding CNS with damage to oligodendrocytes and myelin resulting in more macrophage chemotaxis [15, 16]

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Hospira bacteriostatic water is a sterile water that contains 0.9 % benzyl alcohol as a preservative