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The evidence is provided by: (i) the inhibitors are found in the secondary site known to interact with outgoing NADP + in related pyridine nucleotide–disulfide oxidoreductases

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Gene-expression data suggest that GABA A -receptor physiology may be altered in MDD, but a relative paucity of receptor-binding, protein-expression, and functional assay data has made it difficult to assess whether these changes have translated into altered receptor function, or what the consequences of these changes might be for GABA neurotransmission