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Blocking autoantibodies are highly specific and are present in 70% of pernicious anemia patients (Htut TW, 2021)

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On deeply pigmented skin the contrast between affected and unaffected areas is stark and often distressing, while on very fair skin patches can go unnoticed for a long time, sometimes only revealed when the surrounding skin tans in summer or under a special ultraviolet examination light in the clinic

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