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A 16-week Phase 2 dose-escalation RCT in obese adults without diabetes by Aronne and colleagues in the Journal of Clinical Endocrinology and Metabolism in 2007 showed progressive, dose-dependent weight loss with pramlintide, and a 12-month RCT by Smith and colleagues in Diabetes Care in 2008 demonstrated that pramlintide combined with lifestyle intervention produced approximately 6 to 7 kg placebo-corrected weight loss at one year in obese adults