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Catalpol, from Rehmannia glutinosa , counteracts this by downregulating RhoA/ROCK2 expression and upregulating key TJ proteins ( Panax notoginseng saponins (PNS) reverse the downregulation of ZO-1 and claudin-5 during ischemia-reperfusion injury, thereby preserving TJ integrity ( in vivo evidence for TWLPLPR remains to be established ( 3.2 Mitigation of neuroinflammation Phytochemicals preserve BBB integrity and ameliorate VCI by suppressing neuroinflammation via multifaceted mechanisms