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Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

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The same research group at Seoul National University previously studied minoxidil using the identical DPC model (Han et al., 2004) and found similar proliferative and anti-apoptotic mechanisms