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Blocking L-carnitine synthesis by meldonium prolongs the survival in mice with pancreatic cancer - ScienceDirect

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424,425 Finally, adipokine signaling intersects with these metabolic circuits: leptin and IL-6 not only drive TAM recruitment and polarization but also modulate T-cell metabolism and checkpoint expression, supporting combinatorial strategies that pair CD36/FAO blockade with IL-6/leptin axis modulation to restore antitumor immunity