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The cysteine S -conjugate sulfoxide of tetrachloroethylene (( S -(1,2,2-trichlorovinyl)-l-cysteine, TCVC) was also shown to be nephrotoxic

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Moreover, we further elucidated the mechanism underlying the direct regulation of mitochondria by HIF-1α independently of its nuclear activities, which sheds light on the regulatory role of HIF-1α under hypoxia