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4.1 Endogenous stimuli-responsive hydrogels for targeted cartilage repair in osteoarthritis Cartilage degeneration arises from persistent mechanical loading, oxidative stress, and matrix proteolysis, which reduce chondrocyte number and secretory capacity and thereby weaken intrinsic repair

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Anti-LOX activity was induced through intragastric gavage using a specific LOX inhibitor, beta-aminopropionitrile fumarate, at a dosage of 100 milligrams per kg per day