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In addition, HYAL2 deficiency in humans may be associated with a rare heart disease, Cor triatriatum sinistrum, but the mechanisms involved still need to be further investigated [202]

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Some of the coenzyme Q derivatives, such as idebenone or vatiquinone (EPI-743), have been tested with various models and even subjected to human clinical trials of neurodegenerative diseases, and they seem to have only limited benefit (Gutzmann et al., 2002