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We then examined the correlation between gene expression and metabolic fluxes, and identified the transcriptionally, post-transcriptionally, or metabolically regulated reactions under sucrose to glucose growth transition by resorting to a method that takes into account the direction of change of the in silico fluxes derived from a constraint-based sampling procedure and the corresponding changes to gene expression levels (see Methods)

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Phase II trial of the O 6-alkylguanine DNA alkyltransferase inhibitor O 6-benzylguanine and 1, 3-bis (2-chloroethyl)-1-nitrosourea in advanced melanoma