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Hyperglycemia- and AGE-induced oxidative stress skew macrophages toward the M1 phenotype via NF-κB/STAT1 signaling (54), while chronic hypoxia in advanced disease enhances M2 polarization via hypoxia-inducible factor-1α (HIF-1α)

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B complex vitamins typically contain 50 mcg to 500 mcg of vitamin B12 along with other B vitamins such as folic acid (vitamin B9) and pyridoxine (vitamin B6)