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The combination of the Nrf 2siRNA and EGCG downregulated the intracellular Nrf2 protein levels and reversed the tamoxifen resistance in tamoxifen-resistant MCF-7 (MCF-7/TAM) cells ( Bruceajavanica is a novel inhibitor ofNrf2 that sensitizes HER2-positive cancer cells to trastuzumab both in vitro and in vivo

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Smoking, for example, introduces free radicals into the body, which directly damage cellular structures, as shown by Messner and Bernhard [58]