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While vitamin B 12 deficiency is not a primary test in newborn screening programs, a study showed that markers C3, C3/C2, and C3/C16 exhibit a negative correlation with maternal levels of vitamin B 12 in the first trimester of pregnancy, and thus may bear diagnostic value (Dayaldasani et al., 2014)

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Cryo EM dynamics analysis and post-3D classification of CTR:Cagri/CagriBB complex 3D variability analysis (3DVA) implemented in cryoSPARC v4.4.1 29,39 was performed to interrogate and visualize the dynamics in the complexes as previously described 25