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It is reported that, during the early stages of sepsis, metabolism in tubular epithelial cells can switch from aerobic oxidation to anaerobic glycolysis, suggestive of metabolic reprogramming ( Concerning the wide-ranging effects of metabolic reprogramming, both beneficial and detrimental, further work is warranted for an improved understanding of the role of the different metabolic pathways in sepsis, as well as identifying strategies to improve outcome in septic patients through the regulation of metabolism

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provided evidence for a phosphorylation-dependent mechanism regulating the interaction between Nix and LC3B