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Additionally, NAD + is required for fatty acid metabolism during β-oxidation, glutaminolysis generating α-ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 3,4,5

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On the contrary, after the 2-HIBA administration to skn-1 ::GFP transgenic worms, a higher translocation of the p38 MAPK transcriptional factor SKN-1 was observed in nuclei, as compared to the control population