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For example, ubiquitination of many GPCRs including PAR, histamine (H 1 or H 2 receptor), and prostaglandin EP 2 (EP 4 prostanoid receptor) activates p38 MAPK via a transforming growth factor- β –activated protein kinase 1–binding protein (TAB)1-TAB2–dependent pathway, which occurs through an interaction between TAB2 and K63-linked ubiquitin on the GPCR (Grimsey et al., 2018, 2019)

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Due to its favorable safety profile, our data support further exploring the use of NAC in hospitalized patients with COVID-19 for severe pneumonia, in other settings and eventually with a higher level of evidence with randomized controlled clinical trials