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Apart from SH-SY5Y neurons, 27-OHC, 7β-OHC and 24S-OHC have demonstrated to upregulate CD36 and β1-integrin expressions in SK-N-BE cells, whereas only 24S-OHC induces CD36 and β1-integrin expression in NT-2 human neurons, enhancing adhesion of neuronal cells to Aβ 1–42

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The study design lacked statistical power to investigate age treatment time interactions but it is possible that the supplement may be more beneficial to older horses experiencing inflammaging compared to mature horses with a less inflammatory cellular environment