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Similarly, Bifidobacterium combine with Lactobacillus treatment versus placebo in quiescent UC were terminated early after the 48-week follow-up due to no significant difference was found between the two groups in relapse-free survival [300]

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Physiologically, NRF2 is predominantly sequestered in the cytoplasm through its association with Keap1, which acts as an adaptor to oxidative or electrophilic stressors, such as elevated ROS, conformational changes in Keap1 disrupt its interaction with NRF2, leading to NRF2 stabilization and release (Yamamoto et al., 2018)