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The potential mechanism by which GH may improve spermatogenesis is possibly through the stimulation of Leydig and Sertoli cell differentiation ( When GH-deficient rats were treated with GH, it was demonstrated to have a protective effect on the count and motility of spermatids following treatment with cyclophosphamide (98) In addition, it prevented testicular atrophy and testosterone depletion after treatment with methotrexate (88, 99)