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**Pending indications:** Eli Lilly has ongoing clinical trials investigating tirzepatide for additional indications including obstructive sleep apnea (the SURMOUNT-OSA trial), heart failure with preserved ejection fraction (SUMMIT trial), and non-alcoholic steatohepatitis.[15] If any of these receive FDA approval, the approved label will expand — but until that happens, prescribing tirzepatide specifically for those conditions is off-label use of an approved drug