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Further exploration revealed that this was driven mainly by the difference between patients with ME/CFS and HCs (F = 9.589, p = 0.004), with ME/CFS patients showing higher lactate levels than controls, although a trend towards significant difference between patients with ME/CFS and long COVID was also noted (F = 4.031, p = 0.052)

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139 ) The association between NFS1 activity and cancer relates to temporary abrupt increases in oxygen tensions experienced by cancer cells that differently affect tumours according to their tissue and organ localisation