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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53—commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

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Additionally, BPC 157 treatment, along with L-NAME, nullified any effect of L-NAME that otherwise intensified the regular course