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cleavage of ICAD by caspase-3 triggers its dissociation from CAD, thereby releasing and activating the CAD enzyme, which subsequently enters the nucleus and degrades DNA, generating the characteristic apoptotic DNA ladder)

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No, you cannot overdose on B12 It is highly unlikely that someone could take too much B12, says Natalie Allen, RD, a clinical assistant professor of biomedical sciences at Missouri State University