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The presence of macrophages with various phenotypes is crucial for wound healing, with M2 macrophages playing a pivotal anti-inflammatory role, potentially through the promotion of vascular endothelial growth factor secretion (39, 40)
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Additionally, these agents improve cerebral blood flow, reduce microbleeds and white matter lesions, and promote amyloid clearance through peroxisome proliferator-activated receptor gamma (PPAR-γ) activation, unlike Ang-II inhibiting AHMs, which may impair amyloid degradation 10,36,37