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doi: 10.1111/jpi.12018, PMID: [DOI] [PubMed] [Google Scholar] 105.Srinivasan V, Maestroni G, Cardinali D, Esquifino A, Perumal SP, Miller S

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Under hypoxic conditions, the reduced oxygen availability diminishes the activity of prolyl hydroxylase domain enzymes (PHDs), which typically employ oxygen and α-ketoglutarate as substrates to hydroxylate HIF-1α, thereby targeting it for degradation