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Considering that the overall gene profiling between parental and CYP2D6 + cells demonstrated that transgenic HepaRG cells had kept the ability to differentiate into hepatocyte- and cholangiocyte-like cells, we compared the induction of CYP1A2, CYP2B6 and CYP3A4/5 catalytic activities in both parental and CYP2D6 + differentiated cells treated with canonical inducers omeprazole (CYP1A2), rifampicin (CYP3A4) and phenobarbital (CYP2B6) ( Supporting information 4B )