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Nevertheless, the combination of IGF-1 with PDGF-BB and bFGF proved to be a potent stimulant for ASC proliferation, while combination of IGF-1 (10 ng/mL) with bFGF (10 ng/mL) without PDGF-BB was not able to increase cell proliferation in equine MSCs [87]

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Betaine primarily acts as a methyl donor in the one-carbon metabolism pathway, reducing hyperhomocysteinemia and attenuating cardiovascular risk