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In support of the hypothesis that Aβ42 would damage neuronal membranes in persons carrying the APOE4 gene due to absence of Cys in residues 112 and 158 of apoE4 (206, 209), decreased HNE binding to ApoE4 compared to ApoE3 was observed (216), and ApoE3 was more cross-linked by HNE than was ApoE4 (217)

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