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Endogenous GSTP1-1 is an important target for haptenation, which has been related to the induction of certain drug hypersensitivity reactions (Meng et al., Altogether, these findings support the role of GSTP1-1 as a risk factor in hypersensitivity responses by multiple mechanisms, given its multifunctional involvement in drug metabolism and inflammation

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Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the slc7a11/gpx4 signaling